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Scientific Paper

Detection of nanoscale bioparticles generated from E. coli bacteriophage PhiX174 and bovine serum albumin (BSA) by Asymmetric Flow Field-Flow Fractionation

Reference Type:Journal Article
Author:Sohmen, R.;Stark, U.;Moldenhauer, E.;Klein, T.;Grieshaber, R.
Title:Detection of nanoscale bioparticles generated from E. coli bacteriophage PhiX174 and bovine serum albumin (BSA) by Asymmetric Flow Field-Flow Fractionation
Secondary Title:Gefahrstoffe - Reinhalt. Luft
Periodical Title:Gefahrstoffe - Reinhalt. Luft
Pages:494-497
Volume:72
Number:Copyright (C) 2013 American Chemical Society (ACS). All Rights Reserved.
Year:2012
ISBN:0949-8036

Nanoscale particels are unequivocally part of our daily life and natural environment as polymers, proteins and inorg. material matter. Due to the progress in nanosciences human designed and produced nanoparticles with promising benefits will also have a great impact on occupational health and safety aspects at the workplace. Prevention e.g. cares for the mechanism of liberation of nanoscale particles under working conditions, aerosol generation, exposure level measurements and health care aspects. The main route of uptake is by inhalation, dermal resorption and to the lesser extent by oral uptake. For a preliminary est. of possible adverse effects nanopartices have been characterized in their distinctive particle features with emphasis on airborne particles. To get in contact with human epithelials nanoparticles must be suspended and presumptively will change their aggregation or agglomeration properties. In order to characterize the hydrodynamic parameters of nanoscale bioparticles we used one of the Field flow fractionation (FFF) methods, Asym. Flow Field-Flow Fractionation. An oitment for skin protection endowed with E. coli bacteriophage PhiX174 as an example for a lipophilic and bovine serum albumin (BSA) under hydrophilic conditions were analyzed. [on SciFinder(R)]

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