Company >News & Events >Press Releases

Press Releases

New Book Thermal Field-Flow Fractionation of Polymers

Postnova Analytics reports on an informative new book** that introduces scientists to Thermal Field-Flow Fractionation and discusses its advantages over the fundamental problems associated with traditional column-based analytical techniques commonly used to characterize polymers and macromolecules.

Thermal Field-Flow Fractionation (TF3) is an exciting technique that provides a highly efficient method of separating and characterizing complex polymer samples such as natural or synthetic rubbers, starches and paints from approximately 5 kDa up to 1000 MDa and more in both organic and aqueous solvents. The TF3 technique uses a gentle temperature gradient as the driving force for its separation of polymers and particles, meaning there is no packing material present to interact with the sample and no high shear forces.

Molecules affected by the thermal gradient undergo diffusion which enables separation by both their molar mass and chemical composition. This unique feature allows the separation of different materials having the same molar mass. The separation can be further optimized by the use of different eluents and various temperature programs.

Read more …

The PN3621 Multi-Angle Light Scattering (MALS) detector from Postnova Analytics

The PN3621 Multi-Angle Light Scattering (MALS) detector from Postnova Analytics combines outstanding performance, high precision and reliability design features to facilitate advanced characterization of proteins, conjugates, macromolecules, and nanoparticles.

The PN3621 is commonly used in conjunction with Gel Permeation Chromatography (GPC-MALS), Size Exclusion Chromatography (SEC-MALS) or Field-Flow Fractionation (FFF-MALS) to determine distributions of mass, size and composition independent of column calibration by reference standards.

Designed for many years of reliable, trouble-free operation the customer-friendly PN3621 incorporates a unique vertical ‘clean by design’ flow cell. Unlike MALS instruments with problem prone horizontal flow cells, the vertical cell design 'self-cleans' and also enables large and potentially fragile high molar mass macromolecules to pass through unaltered.

Read more …

Field-Flow Fractionation Improves Characterization of Nanoformulated Medicines

Postnova Analytics reports on a recent independent review** which details how Asymmetric Flow Field-Flow Fractionation (AF4) is a valuable technique to improve the quality of nanoformulated medicines.

Currently, only a few standardized methods exist to characterize some of the crucial physicochemical properties and their impact on biological systems of medical nanoparticles. Unfortunately, they are often not applicable to the more complex and innovative nanoformulations. 

Particle size and size distribution are key factors for the manufacturing quality, as well as the efficacy and safety of medicinal nanoparticles. Despite its widespread usage in the nanomedicine field, batch-mode dynamic light Scattering (DLS) is generally only considered a ‘low-resolution’ method for checking the integrity of monodispersed samples. To overcome the inherent difficulties that are imposed when analysing a polydisperse nanoformulated sample by DLS, a fractionation step should be incorporated prior to measurement. This can be done by using DLS and MALS detectors coupled online to a Postnova Analytics Asymmetric Flow Field Flow Fractionation (AF4) system.

Read more …

Technique for Characterising Liposome Formulated Drugs

Nanoparticles including liposomes are increasingly used for delivery of drug molecules. During formulation of a liposome around a drug particle, a relatively large amount of free drug may remain unencapsulated and therefore not available for drug delivery via the liposomal carrier. For formulation groups adopting this drug delivery methodology it is important to quantify the amount of free versus encapsulated drug in a product in order to accurately determine the delivered dose of drug to a patient.

Read more …

Fast Measurement of Nanocrystal Length & Thickness

Postnova Analytics reports on how Asymmetrical Flow Field-Flow Fractionation coupled to Multi Angle Light Scattering (AF4-MALS) has been successfully used to characterise a polydisperse cellulose nanocrystal for size and thickness in just 40 minutes analysis time.

Read more …

Separation & Characterisation of Self Assembling Block Copolymers

Postnova Analytics reports on how Thermal Field Flow Fractionation has been successfully used to elucidate the core microstructure, morphology and chain arrangement of self-assembling block copolymers. This pioneering study was undertaken by the renowned research group under Professor H Pasch at the Department of Chemistry and Polymer Science, University of Stellenbosch (South Africa).

Read more …

Analysis of Nanoparticles in Commercial Sunscreens

Postnova Analytics has published a new application note that describes a new approach for analysis of titanium dioxide nanoparticles in commercial sunscreens. The technique, which combines Inverse Supercritical Fluid Extraction (I-SFE) and Miniaturized Asymmetrical Flow Field-Flow Fractionation hyphenated with UV-Vis and Multi Angle Light Scattering (mAF4-UV-MALS) represents a promising tool for the verification of the nano-labelling of such products.

Read more …

Comparative Analysis of a Complex Monoclonal Antibody

Postnova Analytics has published a new poster that compares the suitability of Electrical Asymmetrical Flow Field-Flow Fractionation (EAF4) and Size Exclusion Chromatography (SEC) for determining the physicochemical and biophysical attributes of monoclonal antibodies.

Read more …

Efficient Purification of Extreme Viruses

Postnova Analytics announce in a joint collaboration with the Department of Biosciences at the University of Helsinki (Finland), that Asymmetrical Flow Field-Flow Fractionation (AF4) was successfully employed for the purification of halophilic (extreme) viruses.

Read more …

Comparing Methods to Detect, Size and Quantify Silver Nanoparticles

Postnova Analytics report on how researchers from the Institute for Health and Consumer Protection at the European Commission Joint Research Centre (Ispra, Italy) and the University of Ferrara  have used AF2000 Asymmetric Flow Field-Flow Fractionation (AF4) system and Model S101 Sedimentation Flow-Field Fractionation (SdFFF) systems in some ground-breaking research.

Read more …

Measuring Trace Metal Colloid Distribution in The Environment

Postnova Analytics reports on how the SWAMP ultra-clean research facility* at the University of Alberta (Alberta, Canada) has been using the AF2000 Flow field flow fractionation system coupled to Inductively Coupled Plasma Mass Spectrometry (ICP-MS), UV and fluorescence detectors to characterise trace metal colloid distribution in the environment.

Read more …

Characterisation of Nanomaterials in Foods

Postnova Analytics reports on how the inorganic analysis team within LGC (Teddington, UK) has been using the AF2000 Field Flow Fractionation system coupled to Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to characterise nanomaterials in complex food sample matrices.

Read more …

Unlocking the Puzzle of Neurodegenerative Diseases

Postnova Analytics reports that the Department of Molecular Biology & Biotechnology at the University of Sheffield (UK) is using their AF2000 Field Flow Fractionation system to investigate the mechanism of amyloid formation, a protein mis-folding process implicated to be the cause of Alzheimer’s and other neurodegenerative diseases.

Read more …

Separation & Characterisation of Complex Charged Molecules with EAF2000 Electrical and Asymmetrical FFF

Postnova Analytics announces the launch of the EAF2000 - an innovative new simultaneous Electrical and Asymmetrical Flow Field Flow Fractionation (EAF4) system designed to enhance separation and characterisation of biopharmaceutical, environmental and nanomaterials.

Read more …

Quantification & Characterization of Carbon Nanotubes in Complex Matrices

Postnova Analytics has published an application note that describes a new method to characterize and quantify
Multi-Walled Carbon Nanotubes (MWCNTs) in soil samples using Asymmetrical Flow Field-Flow Fractionation
coupled with MALS detection (AF4-MALS).

Read more …

Determining the Size & Chemical Composition of Tattoo Ink Nanoparticles

Postnova Analytics have published an application study detailing how the technique of Field-Flow Fractionation-ICP-MS can be used to study the size and chemical composition of tattoo ink nanoparticles.

Read more …

Postnova Analytics übernimmt Geschäftsbereich Chromatographie-Zubehör der MedChrom GmbH

Die Firma Postnova Analytics GmbH, Landsberg am Lech, hat mit sofortiger Wirkung den Geschäftsbereich Chromatographie-Zubehör und Analytik der MedChrom GmbH übernommen. MedChrom ist eine auf Labor-, Medizin und Chromatographie-Bedarf spezialisierte Firma aus Flörsheim-Dalsheim.

Read more …

Thermal Separation of Complex Polymers

The Postnova TF2000 is an advanced thermal field flow fractionation (TF3) system that provides a highly
efficient method of separating and characterising complex polymer samples . . .

Read more …

High Resolution Separation And Fractionation Of Nanoparticles

The CF2000 Centrifugal Field Flow Fractionation (CF3) system from Postnova Analytics sets a new standard for high resolution separation and fractionation of nanoparticles . . .

Read more …

Speciation Analysis Of Plasma Proteins Using Asymmetric Flow FFF-ICP-MS

Postnova Analytics reports on exciting advances in the analysis of plasma proteins using a hyphenated
system that couples asymmetric flow Field-Flow Fractionation (AF4) . . .

Read more …

Field-Flow Fractionation of Proteins, Macromolecules and Nanoparticles

The Postnova AF2000 MultiFlow is a high performance Flow Field-Flow Fractionation (FFF) platform for separation of proteins, macromolecules and nanoparticles . . .

Read more …

Postnova Analytics opens UK office

Postnova Analytics, the leading international supplier of Field-Flow Fractionation (FFF) systems, has opened a dedicated office to enhance local support for its growing . . .

Read more …

DKSH exclusively distributes Postnova Analytics’ Field-Flow Fractionation systems in Taiwan

DKSH, the leading Market Expansion Services provider with a focus on Asia, and Postnova Analytics, the global leader in Field-Flow Fractionation, have signed an exclusive distribution agreement for Taiwan . . .

Read more …

Postnova Analytics Attend Pittcon 2013 with Award-winning Field-Flow Fractionation CF2000

Postnova Analytics will be exhibiting at Pittcon in Philadelphia, March 17-21, 2013 with their newest award-winning instrument, the CF2000 - the first commercial Centrifugal Field-Flow Fractionation (FFF) system designed for routine use.

Read more …

Postnova Analytics Attending SCM-6 and EWPSC Conferences with Award Winning FFF Technology

Malvern Instruments and Postnova Analytics co-operate to deliver combined solution for characterizing challenging particulate systems

Read more …

Malvern Instruments and Postnova Analytics co-operate

Malvern Instruments and Postnova Analytics co-operate to deliver combined solution for characterizing challenging particulate systems

Read more …

Sitemap